Clinical Presentation and Outcomes of Patients with Light Chain Amyloidosis Who Have Non-Evaluable Free Light Chains at Diagnosis
نویسندگان
چکیده
منابع مشابه
Light-chain (AL) amyloidosis: diagnosis and treatment.
Light-chain (AL) amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. The disease often is difficult to recognize because of its broad range of manifestations and what often are vague symptoms. The clinical syndromes at presentation include nephrotic-range proteinuria with or without renal dysfunction, hepatomegaly, congestive h...
متن کاملAnalysis of free serum light chains in patients suffering from multiple myeloma complicated by light-chain amyloidosis.
BACKGROUND AL amyloidosis is an acquired systemic disease in which a pathologic amorphous substance produced as a result of abnormal protein metabolism is deposited in the extracellular space of various tissues. OBJECTIVES The aim of the study was to investigate the relationship between the kappa and lambda serum free light chains (sFLCs) and the development of AL amyloidosis in patients suff...
متن کاملSerum Free Light-chain Assay for the Diagnosis, Management, and Prognosis of Multiple Myeloma
In recent decades, new serum biomarkers have been developed for routine laboratory practice, such as assaying serum free light chains and more recently, assaying immunoglobulin heavy and light chain isotypes (Hevylite). In this work, we highlight the interest of new biomarkers (Hevylite Test) in the management of monoclonal gammopathies because of the technical advantages it confers and the se...
متن کاملLight chain amyloidosis: a case presentation and review.
n 1977, an asymptomatic 68-year-old woman underwent biopsy of a supraclavicular node that had been detected at the time she presented for breast biopsy. While the breast biopsy was benign, pathology from the lymph node revealed amyloid. For unclear reasons, no further evaluation or treatment was undertaken then. Two years later, a paratracheal node was noted during screening chest xray. Biopsy ...
متن کاملCase for diagnosis. Systemic light chain amyloidosis with cutaneous involvement*
Systemic light chain amiloydosis is a rare disease. Due to its typical cutaneous lesions, dermatologists play an essential role in its diagnosis. Clinical manifestations vary according to the affected organ and are often unspecific. Definitive diagnosis is achieved through biopsy. We report a patient with palpebral amyloidosis, typical bilateral ecchymoses and cardiac involvement, without plasm...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.3272.3272